Abstract 137: Contribution of the Non-Canonical BMP Receptor Signaling Pathway Osteogenesis on Bioinspired Nanoparticulate Mineralized Collagen Scaffolds
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چکیده
PURPOSE: Capillary malformation is a cutaneous vascular anomaly that is present at birth, darkens over time, and can cause overgrowth of tissues beneath the stain. The lesion is caused by a somatic activating mutation in GNAQ. In a previous study we were unable to identify a GNAQ mutation in patients with a capillary malformation involving an overgrown lower extremity. We hypothesized that mutations in GNA11 or GNA14, genes closely related to GNAQ, also may cause capillary malformations.
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